郑州大学附属郑州中心医院细胞研究与转化中心（以下简称中心），是医院重点打造的高水平、开放式、转化型科研平台。旨在贯彻落实国家创新驱动发展战略，提升医院科研竞争力，推动生物医学前沿成果向临床转化。依托该平台，已获批河南省分子肿瘤学医学重点实验室、河南省结直肠癌诊治医学重点实验室、郑州市结直肠癌诊治与研究重点实验室、郑州市自身免疫性内分泌疾病重点实验室。中心的主要研究方向包括：常见恶性肿瘤发生发展新分子机制、靶向干预及抗肿瘤免疫；体细胞/干细胞干预疾病的功能机制及临床研究；神经退行性疾病病因学及药物干预。中心目前有博士6人、硕士9人，正在承担国家级、省部级、市厅级科研课题10余项。近三年，团队成员围绕上述研究方向发表SCI研究论文10余篇，获得科技奖励5项。

   代表工作包括：

   [1]远端缺血预处理可降低法洛四联症儿童术后心肌损伤指标，缩短ICU住院时间，改善短期预后(Eur Heart Journal. 2018; 39(12):1028-1037. Featured/recommended by F1000 Medicine, https://f1000.com/prime/727546806#)。

       [2]高血糖削弱缺血后处理心肌保护作用，通过抑制AdipoR1、Caveolin-3和STAT3信号通路，使缺血后处理丧失对糖尿病大鼠心肌损伤保护作用 (Diabetes. 2016;65(4):942-55, published with editorial mention)。

       [3]丙泊酚通过增强HO-1/STAT3信号，缓解糖尿病大鼠心肌肥大和功能障碍，减少氧化应激和凋亡。(Crit Care Med. 2014 ;42(8):e583-94 published with editorial mention)

       [4]高血糖激活PKCβ2，降低Caveolin-3及Akt/eNOS信号，导致糖尿病大鼠舒张功能障碍(Diabetes. 2013;62(7):2318-2328. Featured by “World Biomedical Frontiers: http://biomedfrontiers.org/diabetes-2013-11-29).

       [5]大剂量丙泊酚在体外循环中可显著降低冠脉手术患者心肌损伤生化指标，其保护作用优于异氟醚。(Anesth Analg. 2006;103(3):527-532. cited in and recommended by 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery. J Am Coll Cardiol. 2011 Dec 6;58(24):e123-210 )

    已发表SCI文章310余篇，总引用2.9万余次，H指数64。2023年全国麻醉医学领域学者学术影响力Top 1，被国际著名医学评级机构（Expertscape）评为2011-2021糖尿病心肌病领域全球Top 1%专家（香港Top 1），及2012-2022实验糖尿病领域全球Top 0.1%专家（香港Top 1），连续4年（2020-2023年）入选斯坦福全球2%顶尖科学家名单。现任中国心胸血管麻醉学会理事，曾任中国心胸血管麻醉学会基础与转化医学分会主任委员。

    近2年发表工作如下：

    [1]1.Bing H, Wang Y, Li S, Li Y, Wang Q, Li L, Liu S, Hu Z, Wang T, Lu Q, Ran R, Wu Y, Xu S, Li H, Huo J, Liu C, Hu A, Xia Z*, Chu Q*. Reinforcement learning based automated anesthesia system for gastrointestinal endoscopy with a multicenter randomized trial. NPJ Digit Med. 2026 Apr 29. doi: 10.1038/s41746-026-02657-8.

         [2]Gao Y, Ma B, Jin R, Shao Y, Zhang L, Qi X, He Q, Chu Q*, Xia Z*. Anhydroicaritin-loaded mesenchymal stem cell exosomes ameliorate psoriasis via ACSL4-mediated ferroptosis in mice. Commun Biol. 2026 Jan 23;9(1):306. doi: 10.1038/s42003-026-09575-1.

         [3]Li S, Cai Y, Xia Z. Editorial: Function and regulation of non-neuronal cells in the nervous system. Front Cell Neurosci. 2025 Feb 7;19:1550903. doi: 10.3389/fncel.2025.1550903. eCollection 2025. PMID: 39990969

         [4]Qin Y, Liao S, Sun J, Ye H, Li J, Pan J, He J, Xia Z*, Shao Y*. RECK as a Potential Crucial Molecule for the Targeted Treatment of Sepsis. J Inflamm Res. 2025 Feb 6;18:1787-1813. doi: 10.2147/JIR.S501856. eCollection 2025. PMID: 39931174

         [5]Peng H, Wen J, Chen M, Xia Z, Jiang Y, Xie K, Huang W, Cui B, Li P, Zhang Y, Wu X. Preoperative Analgesia Efficacy of Liposomal Bupivacaine Following Pericapsular Nerve Group (PENG) Block in Patients with Hip Fracture: A Randomized Controlled Observer-Blinded Study. Pain Ther. 2025 Feb;14(1):283-296. doi: 10.1007/s40122-024-00683-6. Epub 2024 Dec 3. PMID: 39623252

         [6]Han R, Huang H, Zhu J, Jin X, Wang Y, Xu Y, Xia Z*. Adipokines and their potential impacts on susceptibility to myocardial ischemia/reperfusion injury in diabetes. Lipids Health Dis. 2024 Nov 13;23(1):372. doi: 10.1186/s12944-024-02357-w. PMID: 39538244

         [7]Zhou D, Yang Y, Han R, He J, Liu D, Xia W, Cai Y, Perek B, Xia Z*. Ferroptosis and its Potential Determinant Role in Myocardial Susceptibility to Ischemia/Reperfusion Injury in Diabetes. Rev Cardiovasc Med. 2024 Oct 9;25(10):360. doi: 10.31083/j.rcm2510360. eCollection 2024 Oct. PMID: 39484139

         [8]Wang J, Wu Y, Mao M, Bing H, Sun L, Xu W, Tian W, Xia Z, Jin X, Chu Q. Sivelestat Sodium Alleviates Ischemia-Reperfusion-Induced Acute Kidney Injury via Suppressing TLR4/Myd88/NF-κB Signaling Pathway in Mice. Drug Des Devel Ther. 2024 Oct 5;18:4449-4458. doi: 10.2147/DDDT.S480148. eCollection 2024. PMID: 39399126

         [9]Wang Y, Bing H, Jiang C, Wang J, Wang X, Xia Z, Chu Q. Gut microbiota dysbiosis and neurological function recovery after intracerebral hemorrhage: an analysis of clinical samples. Microbiol Spectr. 2024 Nov 5;12(11):e0117824. doi: 10.1128/spectrum.01178-24. Epub 2024 Sep 24.PMID: 39315788

         [10]Yang Y, Chen J, Zhou J, Zhou D, Zhang A, Jiang Y, Lin J, Xia W, Cai Y, Han R, Lu Y, Liu D, Xia Z*.Connexin43 overexpression promoted ferroptosis and increased myocardial vulnerability to ischemia-reperfusion injury in type 1 diabetic mice. Int J Med Sci. 2024 Sep 9;21(12):2365-2378. doi: 10.7150/ijms.95170. eCollection 2024. PMID: 39310260

         [11]Wang Y, Yuan J, Liu H, Chen J, Zou J, Zeng X, Du L, Sun X, Xia Z, Geng Q, Cai Y, Liu J.   Elevated meteorin-like protein from high-intensity interval training improves heart function via AMPK/HDAC4 pathway. Genes Dis. 2023 Sep 14;11(6):101100. doi: 10.1016/j.gendis.2023.101100. eCollection 2024 Nov. PMID: 3928183

         [12]Ji YW, Wen XY, Tang HP, Jin ZS, Su WT, Zhou L, Xia Z, Xia Z, Lei SQ. DJ-1: Potential target for treatment of myocardial ischemia-reperfusion injury. Biomed Pharmacother. 2024 Sep 3;179:117383. doi: 10.1016/j.biopha.2024.117383. 39232383

         [13]Baumgardt SL, Fang J, Fu X, Liu Y, Xia Z, Zhao M, Chen L, Mishra R, Gunasekaran M, Saha P, Forbess JM, Bosnjak ZJ, Camara AK, Kersten JR, Thorp EB, Kaushal S, Ge ZD. Genetic deletion or pharmacologic inhibition of HDAC6 protects the heart against ischemia/reperfusion injury by limiting TNFα-induced mitochondrial injury in experimental diabetes.  Cardiovasc Res. 2024 Jul 13:cvae144. doi: 10.1093/cvr/cvae144.

         [14]Huang Y, Chen L, Li L, Qi Y, Tong H, Wu H, Xu J, Leng L, Cheema S, Sun G, Xia Z, McGuire J, Rodrigues B, Young LH, Bucala R, Qi D. Downregulation of adipose LPL by PAR2 contributes to the development of hypertriglyceridemia. JCI Insight. 2024 Jul 8;9(13):e173240. doi: 10.1172/jci.insight.173240.

         [15]Yanwei Ji, Qi An, Xinyu Wen , Zhou Xu , Zhengyuan Xia , Zhongyuan Xia, Qinyong Hu, Shaoqing Lei. Liver cancer from the perspective of single-cell sequencing: a review combined with bibliometric analysis. J Cancer Res Clin Oncol. 2024 Jun 24;150(6):316.

         [16]Li W, Leng Y, Xiong Y, Li W, Cai Y, Xue R, Chen R, Lei S, Xia Z*, Xia Z*.  DJ-1 preserves ischemic postconditioning-induced cardioprotection in STZ-induced type 1 diabetic rats: role of PTEN and DJ-1 subcellular translocation. Cell Commun Signal. 2024 May 2;22(1):252. doi: 10.1186/s12964-024-01638-2.PMID: 38698453

         [17]Yang Z, Chan YM, Chan DS, Wu C, Wang Z, Jiang Y, Liu D, Xia Z, Zhang L, Cai Y, Wong CY.  A Biomineralized Bifunctional Patient-Friendly Nanosystem for Sustained Glucose Monitoring and Control in Diabetes. Small Methods. 2024 May 2:e2400159. doi: 10.1002/smtd.202400159. Online ahead of print. PMID: 38697928

         [18]Zhou D, Yang Y, Chen J, Zhou J, He J, Liu D, Zhang A, Yuan B, Jiang Y, Xia W, Han R, Xia Z*. N-acetylcysteine Protects Against Myocardial Ischemia-Reperfusion Injury Through Anti-ferroptosis in Type 1 Diabetic Mice. Cardiovasc Toxicol. 2024 May;24(5):481-498. doi: 10.1007/s12012-024-09852-7. Epub 2024 Apr 22.PMID: 38647950

         [19]Luo S, Xu R, Xie P, Liu X, Ling C, Liu Y, Zhang X, Xia Z, Chen Z, Tang J. EGFR of platelet regulates macrophage activation and bacterial phagocytosis function. J Inflamm (Lond). 2024 Apr 17;21(1):10. doi: 10.1186/s12950-024-00382-1. PMID: 38632608

         [20]Zhou J, Xia W, Chen J, Han K, Jiang Y, Zhang A, Zhou D, Liu D, Lin J, Cai Y, Chen G, Zhang L, Xu A, Xu Y, Han R*, Xia Z*. Propofol and salvianolic acid A synergistically attenuated cardiac ischemia-reperfusion injury in diabetic mice via modulating the CD36/AMPK pathway. Burns Trauma. 2024 Apr 9;12:tkad055. doi: 10.1093/burnst/tkad055. eCollection 2024. PMID: 38601971

         [21]Xia W, Zhang M, Liu C, Wang S, Xu A, Xia Z, Pang L, Cai Y. Exploring the therapeutic potential of tetrahydrobiopterin for heart failure with preserved ejection fraction: A path forward.  Life Sci. 2024 May 15;345:122594. doi: 10.1016/j.lfs.2024.122594. Epub 2024 Mar 25.PMID: 38537900